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James O'Connell refers to himself as a "street doctor." Since 1985, he has cared for homeless patients, sometimes making visits on park benches or in alleys. His memoir is Stories from the Shadows.

As the U.S. investigates a shooting in California as "an act of terrorism," President Obama will address the nation Sunday night in what will be just his third speech from the Oval Office.

Up until now, women in Saudi Arabia had been barred from participating in elections — both as candidates and voters. Saudi women are still banned from driving.

Online habits may be shifting to social media, but email is still the be-all and end-all for grass-roots political fundraising. Get ready for your inbox to be flooded.

The two fighters went 12 rounds but Floyd Mayweather won the welterweight title in Las Vegas Saturday. They each stand to earn millions.

The agency that administers Obamacare in California moved to make expensive medicines more affordable in 2016. In most plans, patients will pay no more than $150 or $250 a month.

Early experiments in isolating inmates took place at a Philadelphia prison in the 1800s. Though discredited as cruel, the practice was later revived nationwide during the drug war.

The Donald Trump-Jeb Bush feud has spilled over into Instagram, which was one of the tamer social media outlets. Not anymore.

Until recently, retired Marine Gen. John Allen led the U.S.-led coalition against ISIS. NPR's Rachel Martin speaks with Allen about U.S. strategy in Iraq and Syria and whether it's working.

Colorado voters made the state the first to legalize recreational pot. In 2016, a ballot initiative could establish another first: a single-payer health system that provides universal coverage.