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Drugmakers have brought almost 450 orphan drugs to market and collected rich incentives by doing so. But nearly a third of the medicines aren't new or were repurposed many times for financial gain.

The blaze north of Santa Barbara has forced as many as 6,000 people to evacuate homes and campsites. It's thought the fire began Monday at a campsite in the Los Padres National Forest. So far, more than 1,000 acres have been burned. It may be a week before the fire is contained.

Instead of buying Time Warner for a reported $80 billion, Twenty-First Century Fox will buy back $6 billion worth of shares of its own stock.

Jacob Montgomery's apartment was destroyed last week when a tornado ripped through Washington, Ill. The Illinois Guardsman survived, but was separated from his 6-month-old pit bull named Dexter. Nine days later, something amazing happened.

About 50 passengers were aboard the Red Line train when it left the Braintree station south of Boston about 6 a.m. Thursday.

The economy performed better than expected in the July-September period, after making a 4.6 percent jump in the second quarter of the year.

A change in federal law could mean trucks with double trailers, more than 80 feet in overall length will be driving on upstate New York roads and…

Rescue efforts continue in the city of Tainan, where a magnitude 6.4 quake struck early Saturday. News services report two of the dead are a baby and an adult man. Some 120,000 are without power.

The flooding north of Chicago has affected some 6,800 buildings and is "unprecedented," Illinois officials said. It's expected to worsen this weekend.

The unseeded Latvian shocked Simona Halep on Saturday, winning her first major in dramatic fashion. Ostapenko overcame dozens of unforced errors on the strength of a number of stunning shots.